| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359). . |
| GO - Molecular function |
- lipopeptide binding : IDA:AgBase
- lipopolysaccharide binding : IDA:MGI
- lipoteichoic acid binding : IDA:MGI
- signaling receptor binding : ISS:BHF-UCL
|
| GO - Biological process |
- acute-phase response : IEP:BHF-UCL
- cellular defense response : ISS:BHF-UCL
- cellular response to lipopolysaccharide : IDA:MGI
- cellular response to lipoteichoic acid : IDA:MGI
- cytokine-mediated signaling pathway : TAS:Reactome
- defense response to Gram-negative bacterium : IDA:BHF-UCL
- defense response to Gram-positive bacterium : IDA:BHF-UCL
- detection of molecule of bacterial origin : IDA:BHF-UCL
- innate immune response : ISS:BHF-UCL
- leukocyte chemotaxis involved in inflammatory response : IEA:Ensembl
- lipopolysaccharide transport : IDA:BHF-UCL
- lipopolysaccharide-mediated signaling pathway : IDA:BHF-UCL
- macromolecule localization : IDA:AgBase
- macrophage activation involved in immune response : IMP:UniProtKB
- negative regulation of growth of symbiont in host : IEA:Ensembl
- negative regulation of tumor necrosis factor production : IDA:BHF-UCL
- opsonization : ISS:BHF-UCL
- positive regulation of chemokine production : IEA:Ensembl
- positive regulation of cytolysis : IDA:AgBase
- positive regulation of interleukin-6 production : IDA:BHF-UCL
- positive regulation of interleukin-8 production : IDA:BHF-UCL
- positive regulation of macrophage activation : IDA:BHF-UCL
- positive regulation of neutrophil chemotaxis : IEA:Ensembl
- positive regulation of respiratory burst involved in inflammatory response : ISS:BHF-UCL
- positive regulation of toll-like receptor 4 signaling pathway : IDA:BHF-UCL
- positive regulation of tumor necrosis factor biosynthetic process : IEA:Ensembl
- positive regulation of tumor necrosis factor production : IDA:BHF-UCL
- response to lipopolysaccharide : IDA:BHF-UCL
- toll-like receptor 4 signaling pathway : TAS:Reactome
- toll-like receptor signaling pathway : TAS:Reactome
|