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139984

Metalloproteinase inhibitor 2 (P16035)

Uniprot ID P16035
Protein Name Metalloproteinase inhibitor 2
Gene Name TIMP2
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. .
GO - Molecular function
  • integrin binding : IEA:Ensembl
  • metalloendopeptidase inhibitor activity : TAS:ProtInc
  • peptidase inhibitor activity : IDA:UniProtKB
  • protease binding : IPI:UniProtKB
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • aging : IEA:Ensembl
  • central nervous system development : IEA:Ensembl
  • extracellular matrix disassembly : TAS:Reactome
  • negative regulation of cell proliferation : IEA:Ensembl
  • negative regulation of membrane protein ectodomain proteolysis : IBA:GO_Central
  • negative regulation of metallopeptidase activity : IDA:UniProtKB
  • negative regulation of mitotic cell cycle : IEA:Ensembl
  • negative regulation of Ras protein signal transduction : IEA:Ensembl
  • neutrophil degranulation : TAS:Reactome
  • positive regulation of adenylate cyclase activity : IEA:Ensembl
  • positive regulation of MAPK cascade : IEA:Ensembl
  • positive regulation of neuron differentiation : IEA:Ensembl
  • regulation of Rap protein signal transduction : IEA:Ensembl
  • response to cytokine : IBA:GO_Central
  • response to drug : IEA:Ensembl
  • response to hormone : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.