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139979

Insulin-degrading enzyme (P14735)

Uniprot ID P14735
Protein Name Insulin-degrading enzyme
Gene Name IDE
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. .(Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV). {ECO:0000269|PubMed:17055432, ECO:0000269|PubMed:17553876}.
GO - Molecular function
  • amyloid-beta binding : IEA:Ensembl
  • ATP binding : IDA:UniProtKB
  • ATPase activity : IEA:Ensembl
  • beta-endorphin binding : IEA:Ensembl
  • identical protein binding : IPI:IntAct
  • insulin binding : IDA:UniProtKB
  • metalloendopeptidase activity : IDA:UniProtKB
  • peptide binding : IPI:UniProtKB
  • protein homodimerization activity : IPI:UniProtKB
  • signaling receptor binding : IPI:UniProtKB
  • ubiquitin-dependent protein binding : IPI:UniProtKB
  • virus receptor activity : IEA:UniProtKB-KW
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • amyloid-beta clearance : ISS:ARUK-UCL
  • amyloid-beta metabolic process : IDA:UniProtKB
  • bradykinin catabolic process : IDA:UniProtKB
  • determination of adult lifespan : IDA:UniProtKB
  • hormone catabolic process : IEA:Ensembl
  • insulin catabolic process : IDA:UniProtKB
  • insulin metabolic process : IDA:UniProtKB
  • insulin receptor signaling pathway : NAS:UniProtKB
  • negative regulation of proteolysis : IEA:Ensembl
  • positive regulation of protein catabolic process : TAS:ARUK-UCL
  • positive regulation of protein oligomerization : IDA:UniProtKB
  • protein heterooligomerization : IEA:Ensembl
  • protein homooligomerization : IDA:UniProtKB
  • protein homotetramerization : IEA:Ensembl
  • protein targeting to peroxisome : TAS:Reactome
  • proteolysis : IDA:UniProtKB
  • proteolysis involved in cellular protein catabolic process : IDA:UniProtKB
  • ubiquitin recycling : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.