Glial fibrillary acidic protein (P14136)

Uniprot ID P14136
Protein Name Glial fibrillary acidic protein
Gene Name GFAP
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
GO - Molecular function
  • identical protein binding : IPI:IntAct
  • integrin binding : IEA:Ensembl
  • kinase binding : IEA:Ensembl
  • structural constituent of cytoskeleton : TAS:ProtInc
GO - Biological process
  • astrocyte development : IEA:Ensembl
  • Bergmann glial cell differentiation : IEA:Ensembl
  • extracellular matrix organization : IEA:Ensembl
  • intermediate filament organization : IDA:UniProtKB
  • long-term synaptic potentiation : IEA:Ensembl
  • negative regulation of neuron projection development : IEA:Ensembl
  • neuron projection regeneration : IEA:Ensembl
  • positive regulation of Schwann cell proliferation : IEA:Ensembl
  • regulation of chaperone-mediated autophagy : ISS:ParkinsonsUK-UCL
  • regulation of neurotransmitter uptake : IEA:Ensembl
  • regulation of protein complex assembly : TAS:ParkinsonsUK-UCL
  • response to wounding : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.