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139977

Tissue factor (P13726)

Uniprot ID P13726
Protein Name Tissue factor
Gene Name F3
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. .
GO - Molecular function
  • cytokine receptor activity : IBA:GO_Central
  • phospholipid binding : IDA:BHF-UCL
  • protease binding : IPI:BHF-UCL
GO - Biological process
  • activation of blood coagulation via clotting cascade : IC:BHF-UCL
  • activation of cysteine-type endopeptidase activity involved in apoptotic process : IDA:BHF-UCL
  • activation of plasma proteins involved in acute inflammatory response : IDA:BHF-UCL
  • blood coagulation : IDA:BHF-UCL
  • blood coagulation, extrinsic pathway : TAS:Reactome
  • cytokine-mediated signaling pathway : IBA:GO_Central
  • positive regulation of angiogenesis : IDA:BHF-UCL
  • positive regulation of cell migration : TAS:BHF-UCL
  • positive regulation of endothelial cell proliferation : IDA:BHF-UCL
  • positive regulation of platelet-derived growth factor receptor signaling pathway : IDA:BHF-UCL
  • positive regulation of positive chemotaxis : IC:BHF-UCL
  • positive regulation of protein kinase B signaling : IMP:BHF-UCL
  • protein processing : IDA:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.