| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). . |
| GO - Molecular function |
- cytokine activity : IDA:BHF-UCL
- growth factor activity : IDA:BHF-UCL
- oncostatin-M receptor binding : IPI:BHF-UCL
|
| GO - Biological process |
- cytokine-mediated signaling pathway : TAS:Reactome
- immune response : IEA:InterPro
- multicellular organism development : TAS:ProtInc
- negative regulation of cell population proliferation : TAS:ProtInc
- negative regulation of hormone secretion : IDA:MGI
- oncostatin-M-mediated signaling pathway : IDA:BHF-UCL
- positive regulation of acute inflammatory response : IC:BHF-UCL
- positive regulation of cell division : IEA:UniProtKB-KW
- positive regulation of cell population proliferation : IDA:BHF-UCL
- positive regulation of inflammatory response : IDA:BHF-UCL
- positive regulation of interleukin-17 secretion : IDA:BHF-UCL
- positive regulation of MAPK cascade : IDA:MGI
- positive regulation of peptidyl-serine phosphorylation : IDA:MGI
- positive regulation of peptidyl-tyrosine phosphorylation : IDA:BHF-UCL
- positive regulation of phosphatidylinositol 3-kinase signaling : IGI:BHF-UCL
- positive regulation of protein kinase B signaling : IGI:BHF-UCL
- positive regulation of transcription by RNA polymerase II : IDA:MGI
- positive regulation of tyrosine phosphorylation of STAT protein : IDA:CACAO
- regulation of growth : IEA:UniProtKB-KW
- regulation of hematopoietic stem cell differentiation : TAS:GO_Central
|