Proliferating cell nuclear antigen (P12004)

Uniprot ID P12004
Protein Name Proliferating cell nuclear antigen
Gene Name PCNA
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. .
GO - Molecular function
  • chromatin binding : IDA:UniProtKB
  • damaged DNA binding : IDA:UniProtKB
  • dinucleotide insertion or deletion binding : IDA:BHF-UCL
  • DNA polymerase binding : IPI:UniProtKB
  • DNA polymerase processivity factor activity : IBA:GO_Central
  • enzyme binding : IPI:BHF-UCL
  • estrogen receptor binding : IEA:Ensembl
  • histone acetyltransferase binding : IPI:UniProtKB
  • identical protein binding : IPI:IntAct
  • MutLalpha complex binding : IDA:HGNC
  • purine-specific mismatch base pair DNA N-glycosylase activity : IDA:BHF-UCL
  • receptor tyrosine kinase binding : IPI:UniProtKB
GO - Biological process
  • cell proliferation : TAS:ProtInc
  • cellular response to hydrogen peroxide : IEA:Ensembl
  • cellular response to UV : IDA:UniProtKB
  • DNA damage response, detection of DNA damage : TAS:Reactome
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest : TAS:Reactome
  • epithelial cell differentiation : IEP:UniProtKB
  • error-free translesion synthesis : TAS:Reactome
  • error-prone translesion synthesis : TAS:Reactome
  • estrous cycle : IEA:Ensembl
  • heart development : IEA:Ensembl
  • leading strand elongation : IBA:GO_Central
  • liver regeneration : IEA:Ensembl
  • mismatch repair : IDA:BHF-UCL
  • mitotic telomere maintenance via semi-conservative replication : ISS:BHF-UCL
  • nucleotide-excision repair, DNA gap filling : TAS:Reactome
  • nucleotide-excision repair, DNA incision : TAS:Reactome
  • nucleotide-excision repair, DNA incision, 5'-to lesion : TAS:Reactome
  • positive regulation of deoxyribonuclease activity : IDA:UniProtKB
  • positive regulation of DNA repair : IMP:UniProtKB
  • positive regulation of DNA replication : IMP:UniProtKB
  • protein ubiquitination : TAS:Reactome
  • regulation of transcription involved in G1/S transition of mitotic cell cycle : TAS:Reactome
  • replication fork processing : ISS:BHF-UCL
  • response to cadmium ion : IEA:Ensembl
  • response to dexamethasone : IEA:Ensembl
  • response to estradiol : IEA:Ensembl
  • response to L-glutamate : IEA:Ensembl
  • telomere maintenance : TAS:Reactome
  • telomere maintenance via semi-conservative replication : TAS:Reactome
  • transcription-coupled nucleotide-excision repair : TAS:Reactome
  • translesion synthesis : IDA:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.