Signal peptide(a) |
N |
Secretome P(b) |
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Function |
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. . |
GO - Molecular function |
- chromatin binding : IDA:UniProtKB
- damaged DNA binding : IDA:UniProtKB
- dinucleotide insertion or deletion binding : IDA:BHF-UCL
- DNA polymerase binding : IPI:UniProtKB
- DNA polymerase processivity factor activity : IBA:GO_Central
- enzyme binding : IPI:BHF-UCL
- estrogen receptor binding : IEA:Ensembl
- histone acetyltransferase binding : IPI:UniProtKB
- identical protein binding : IPI:IntAct
- MutLalpha complex binding : IDA:HGNC
- purine-specific mismatch base pair DNA N-glycosylase activity : IDA:BHF-UCL
- receptor tyrosine kinase binding : IPI:UniProtKB
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GO - Biological process |
- cell proliferation : TAS:ProtInc
- cellular response to hydrogen peroxide : IEA:Ensembl
- cellular response to UV : IDA:UniProtKB
- DNA damage response, detection of DNA damage : TAS:Reactome
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest : TAS:Reactome
- epithelial cell differentiation : IEP:UniProtKB
- error-free translesion synthesis : TAS:Reactome
- error-prone translesion synthesis : TAS:Reactome
- estrous cycle : IEA:Ensembl
- heart development : IEA:Ensembl
- leading strand elongation : IBA:GO_Central
- liver regeneration : IEA:Ensembl
- mismatch repair : IDA:BHF-UCL
- mitotic telomere maintenance via semi-conservative replication : ISS:BHF-UCL
- nucleotide-excision repair, DNA gap filling : TAS:Reactome
- nucleotide-excision repair, DNA incision : TAS:Reactome
- nucleotide-excision repair, DNA incision, 5'-to lesion : TAS:Reactome
- positive regulation of deoxyribonuclease activity : IDA:UniProtKB
- positive regulation of DNA repair : IMP:UniProtKB
- positive regulation of DNA replication : IMP:UniProtKB
- protein ubiquitination : TAS:Reactome
- regulation of transcription involved in G1/S transition of mitotic cell cycle : TAS:Reactome
- replication fork processing : ISS:BHF-UCL
- response to cadmium ion : IEA:Ensembl
- response to dexamethasone : IEA:Ensembl
- response to estradiol : IEA:Ensembl
- response to L-glutamate : IEA:Ensembl
- telomere maintenance : TAS:Reactome
- telomere maintenance via semi-conservative replication : TAS:Reactome
- transcription-coupled nucleotide-excision repair : TAS:Reactome
- translesion synthesis : IDA:UniProtKB
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