| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). . |
| GO - Molecular function |
- calcium-dependent protein kinase C activity : IDA:UniProtKB
- CCR1 chemokine receptor binding : IPI:UniProtKB
- CCR5 chemokine receptor binding : IPI:UniProtKB
- chemoattractant activity : IDA:UniProtKB
- chemokine activity : IDA:UniProtKB
- identical protein binding : IPI:IntAct
- kinase activity : IDA:UniProtKB
- phospholipase activator activity : IDA:UniProtKB
- protein kinase activity : IDA:UniProtKB
|
| GO - Biological process |
- astrocyte cell migration : ISS:UniProtKB
- calcium ion transport : IDA:UniProtKB
- calcium-mediated signaling : IDA:UniProtKB
- cell activation : IDA:UniProtKB
- cell-cell signaling : IDA:UniProtKB
- cellular calcium ion homeostasis : IDA:UniProtKB
- cellular response to interferon-gamma : IEP:UniProtKB
- cellular response to interleukin-1 : IEP:UniProtKB
- cellular response to organic cyclic compound : IDA:UniProtKB
- cellular response to tumor necrosis factor : IEP:UniProtKB
- chemokine-mediated signaling pathway : IBA:GO_Central
- chemotaxis : IDA:UniProtKB
- cytokine-mediated signaling pathway : TAS:Reactome
- cytoskeleton organization : IDA:UniProtKB
- eosinophil chemotaxis : IDA:UniProtKB
- eosinophil degranulation : IDA:UniProtKB
- exocytosis : IDA:UniProtKB
- G-protein coupled receptor signaling pathway : IBA:GO_Central
- granulocyte chemotaxis : IDA:UniProtKB
- inflammatory response : IDA:UniProtKB
- lipopolysaccharide-mediated signaling pathway : IDA:UniProtKB
- lymphocyte chemotaxis : IDA:UniProtKB
- macrophage chemotaxis : ISS:UniProtKB
- MAPK cascade : IMP:UniProtKB
- monocyte chemotaxis : IDA:UniProtKB
- negative regulation by host of viral transcription : IDA:UniProtKB
- negative regulation of bone mineralization : IDA:UniProtKB
- negative regulation of gene expression : IDA:UniProtKB
- negative regulation of osteoclast differentiation : IDA:UniProtKB
- neutrophil chemotaxis : IDA:UniProtKB
- osteoblast differentiation : IEP:UniProtKB
- positive regulation of calcium ion import : TAS:BHF-UCL
- positive regulation of calcium ion transport : IDA:UniProtKB
- positive regulation of calcium-mediated signaling : IMP:UniProtKB
- positive regulation of cell migration : IDA:UniProtKB
- positive regulation of ERK1 and ERK2 cascade : IDA:UniProtKB
- positive regulation of gene expression : IDA:UniProtKB
- positive regulation of GTPase activity : IBA:GO_Central
- positive regulation of inflammatory response : ISS:UniProtKB
- positive regulation of interleukin-1 beta secretion : ISS:UniProtKB
- positive regulation of natural killer cell chemotaxis : IDA:UniProtKB
- positive regulation of neuron apoptotic process : ISS:UniProtKB
- positive regulation of protein kinase B signaling : IEP:UniProtKB
- positive regulation of tumor necrosis factor production : ISS:UniProtKB
- protein kinase B signaling : IMP:UniProtKB
- regulation of behavior : IDA:UniProtKB
- regulation of cell shape : IDA:UniProtKB
- regulation of sensory perception of pain : IDA:UniProtKB
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum : IDA:UniProtKB
- response to cholesterol : IDA:UniProtKB
- response to toxic substance : IDA:UniProtKB
- signaling : IEP:UniProtKB
- T cell chemotaxis : IDA:UniProtKB
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