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139965

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (P09936)

Uniprot ID P09936
Protein Name Ubiquitin carboxyl-terminal hydrolase isozyme L1
Gene Name UCHL1
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (PubMed:9774100, PubMed:8639624, PubMed:12408865, PubMed:23359680). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (PubMed:12408865). .
GO - Molecular function
  • alpha-2A adrenergic receptor binding : IPI:BHF-UCL
  • cysteine-type endopeptidase activity : IDA:UniProtKB
  • ligase activity : IEA:InterPro
  • omega peptidase activity : IDA:UniProtKB
  • thiol-dependent ubiquitin-specific protease activity : IDA:UniProtKB
  • thiol-dependent ubiquitinyl hydrolase activity : TAS:Reactome
  • ubiquitin binding : IDA:UniProtKB
  • ubiquitin protein ligase binding : IPI:ParkinsonsUK-UCL
GO - Biological process
  • adult walking behavior : IEA:Ensembl
  • axon target recognition : IEA:Ensembl
  • axonal transport of mitochondrion : IEA:Ensembl
  • cell population proliferation : IEA:Ensembl
  • cellular response to drug : IEA:Ensembl
  • eating behavior : IEA:Ensembl
  • muscle fiber development : IEA:Ensembl
  • negative regulation of MAP kinase activity : IDA:BHF-UCL
  • neuromuscular process : IEA:Ensembl
  • proteasome-mediated ubiquitin-dependent protein catabolic process : NAS:ParkinsonsUK-UCL
  • protein deubiquitination : IDA:UniProtKB
  • regulation of macroautophagy : TAS:ParkinsonsUK-UCL
  • response to ischemia : IEA:Ensembl
  • sensory perception of pain : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.