Gamma-enolase (P09104)

Uniprot ID P09104
Protein Name Gamma-enolase
Gene Name ENO2
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). .
GO - Molecular function
  • magnesium ion binding : IEA:InterPro
  • phosphopyruvate hydratase activity : ISS:CAFA
GO - Biological process
  • canonical glycolysis : TAS:Reactome
  • gluconeogenesis : TAS:Reactome
  • glycolytic process : ISS:CAFA
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.