Vimentin (P08670)

Uniprot ID P08670
Protein Name Vimentin
Gene Name VIM
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. .Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}.
GO - Molecular function
  • double-stranded RNA binding : IDA:MGI
  • identical protein binding : IPI:IntAct
  • keratin filament binding : IPI:AgBase
  • protein domain specific binding : IPI:UniProtKB
  • scaffold protein binding : IPI:BHF-UCL
  • structural constituent of cytoskeleton : IDA:UniProtKB
  • structural constituent of eye lens : IEA:Ensembl
GO - Biological process
  • astrocyte development : IEA:Ensembl
  • Bergmann glial cell differentiation : IEA:Ensembl
  • cellular response to interferon-gamma : IEA:Ensembl
  • cellular response to lipopolysaccharide : IMP:UniProtKB
  • cellular response to muramyl dipeptide : IMP:UniProtKB
  • cytokine-mediated signaling pathway : TAS:Reactome
  • intermediate filament organization : IEA:Ensembl
  • lens fiber cell development : IEA:Ensembl
  • muscle filament sliding : TAS:Reactome
  • negative regulation of neuron projection development : IEA:Ensembl
  • positive regulation of collagen biosynthetic process : IMP:UniProtKB
  • positive regulation of translation : IMP:UniProtKB
  • regulation of mRNA stability : IMP:UniProtKB
  • SMAD protein signal transduction : IEA:Ensembl
  • viral process : IEA:UniProtKB-KW
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.