Monocyte differentiation antigen CD14 (P08571)

Uniprot ID	P08571
Protein Name	Monocyte differentiation antigen CD14
Gene Name	CD14
Species	Homo sapiens (Human)

Signal peptide^(a)	Y	Secretome P^(b)
Function	Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). .
GO - Molecular function	lipopeptide binding : IDA:AgBase lipopolysaccharide binding : IDA:MGI lipoteichoic acid binding : IDA:MGI opsonin receptor activity : TAS:BHF-UCL peptidoglycan receptor activity : TAS:ProtInc
GO - Biological process	apoptotic process : TAS:ProtInc apoptotic signaling pathway : TAS:Reactome cell surface receptor signaling pathway : TAS:ProtInc cellular response to diacyl bacterial lipopeptide : IDA:UniProtKB cellular response to lipopolysaccharide : IDA:MGI cellular response to lipoteichoic acid : IDA:MGI cellular response to molecule of bacterial origin : IDA:CAFA cellular response to triacyl bacterial lipopeptide : IDA:UniProtKB I-kappaB kinase/NF-kappaB signaling : TAS:Reactome inflammatory response : IEA:UniProtKB-KW innate immune response : IEA:UniProtKB-KW lipopolysaccharide-mediated signaling pathway : IEA:Ensembl MyD88-dependent toll-like receptor signaling pathway : TAS:Reactome MyD88-independent toll-like receptor signaling pathway : TAS:Reactome necroptotic process : TAS:Reactome negative regulation of MyD88-independent toll-like receptor signaling pathway : TAS:Reactome neutrophil degranulation : TAS:Reactome phagocytosis : TAS:ProtInc positive regulation of endocytosis : IEA:Ensembl positive regulation of interferon-gamma production : ISS:UniProtKB positive regulation of interleukin-8 secretion : IMP:CAFA positive regulation of NIK/NF-kappaB signaling : IDA:AgBase positive regulation of tumor necrosis factor production : IDA:AgBase positive regulation of type I interferon production : IEA:Ensembl receptor-mediated endocytosis : IEA:Ensembl response to electrical stimulus : IEA:Ensembl response to ethanol : IEA:Ensembl response to heat : IEA:Ensembl response to magnesium ion : IEA:Ensembl response to tumor necrosis factor : IEA:Ensembl toll-like receptor 4 signaling pathway : ISS:UniProtKB toll-like receptor signaling pathway : TAS:Reactome toll-like receptor TLR1 : TAS:Reactome toll-like receptor TLR6 : TAS:Reactome TRIF-dependent toll-like receptor signaling pathway : TAS:Reactome

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}