Pleckstrin (P08567)

Uniprot ID P08567
Protein Name Pleckstrin
Gene Name PLEK
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Major protein kinase C substrate of platelets.
GO - Molecular function
  • phosphatidylinositol-3,4-bisphosphate binding : IDA:BHF-UCL
  • protein homodimerization activity : IDA:BHF-UCL
  • protein kinase C binding : IDA:BHF-UCL
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding : ISM:NTNU_SB
GO - Biological process
  • actin cytoskeleton reorganization : IDA:BHF-UCL
  • cell projection organization : IDA:BHF-UCL
  • cortical actin cytoskeleton organization : IDA:BHF-UCL
  • hematopoietic progenitor cell differentiation : IEP:BHF-UCL
  • integrin-mediated signaling pathway : IDA:BHF-UCL
  • negative regulation of calcium-mediated signaling : NAS:BHF-UCL
  • negative regulation of G-protein coupled receptor protein signaling pathway : IDA:BHF-UCL
  • negative regulation of inositol phosphate biosynthetic process : IDA:BHF-UCL
  • phosphatidylinositol metabolic process : IDA:BHF-UCL
  • phospholipase C-inhibiting G-protein coupled receptor signaling pathway : IDA:BHF-UCL
  • platelet aggregation : HMP:UniProtKB
  • platelet degranulation : IEP:BHF-UCL
  • positive regulation of actin filament bundle assembly : IDA:BHF-UCL
  • positive regulation of actin filament depolymerization : IDA:BHF-UCL
  • positive regulation of inositol-polyphosphate 5-phosphatase activity : IDA:BHF-UCL
  • positive regulation of integrin activation : ISS:BHF-UCL
  • positive regulation of platelet activation : ISS:BHF-UCL
  • protein kinase C signaling : ISS:BHF-UCL
  • protein secretion by platelet : ISS:BHF-UCL
  • regulation of cell diameter : IDA:BHF-UCL
  • ruffle organization : IDA:BHF-UCL
  • thrombin-activated receptor signaling pathway : IDA:BHF-UCL
  • vesicle docking involved in exocytosis : ISS:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.