Adenine phosphoribosyltransferase (P07741)

Uniprot ID P07741
Protein Name Adenine phosphoribosyltransferase
Gene Name APRT
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
GO - Molecular function
  • adenine binding : IEA:Ensembl
  • adenine phosphoribosyltransferase activity : TAS:Reactome
  • AMP binding : IDA:MGI
GO - Biological process
  • adenine salvage : IEA:Ensembl
  • AMP salvage : IEA:UniProtKB-UniPathway
  • cellular response to insulin stimulus : IEA:Ensembl
  • grooming behavior : IEA:Ensembl
  • lactation : IEA:Ensembl
  • neutrophil degranulation : TAS:Reactome
  • purine ribonucleoside salvage : IEA:UniProtKB-KW
  • purine-containing compound salvage : TAS:Reactome
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.