Glucose-6-phosphate isomerase (P06744)

Uniprot ID P06744
Protein Name Glucose-6-phosphate isomerase
Gene Name GPI
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. .
GO - Molecular function
  • cytokine activity : IEA:UniProtKB-KW
  • glucose-6-phosphate isomerase activity : TAS:Reactome
  • growth factor activity : IEA:UniProtKB-KW
  • ubiquitin protein ligase binding : IPI:ParkinsonsUK-UCL
GO - Biological process
  • canonical glycolysis : TAS:Reactome
  • carbohydrate metabolic process : NAS:ProtInc
  • gluconeogenesis : TAS:Reactome
  • hemostasis : TAS:ProtInc
  • humoral immune response : TAS:ProtInc
  • neutrophil degranulation : TAS:Reactome
  • positive regulation of endothelial cell migration : IDA:UniProtKB
  • positive regulation of immunoglobulin secretion : IDA:CAFA
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.