Signal peptide(a) |
N |
Secretome P(b) |
|
Function |
Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. . |
GO - Molecular function |
- cytokine activity : IEA:UniProtKB-KW
- glucose-6-phosphate isomerase activity : TAS:Reactome
- growth factor activity : IEA:UniProtKB-KW
- ubiquitin protein ligase binding : IPI:ParkinsonsUK-UCL
|
GO - Biological process |
- canonical glycolysis : TAS:Reactome
- carbohydrate metabolic process : NAS:ProtInc
- gluconeogenesis : TAS:Reactome
- hemostasis : TAS:ProtInc
- humoral immune response : TAS:ProtInc
- neutrophil degranulation : TAS:Reactome
- positive regulation of endothelial cell migration : IDA:UniProtKB
- positive regulation of immunoglobulin secretion : IDA:CAFA
|