Intercellular adhesion molecule 1 (P05362)

Uniprot ID	P05362
Protein Name	Intercellular adhesion molecule 1
Gene Name	ICAM1
Species	Homo sapiens (Human)

Signal peptide^(a)	Y	Secretome P^(b)
Function	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. .(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. {ECO:0000269\|PubMed:1968231, ECO:0000269\|PubMed:2538243}.(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269\|PubMed:11160747, ECO:0000269\|PubMed:16004874, ECO:0000269\|PubMed:9539703}.(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. {ECO:0000269\|PubMed:11413168}.
GO - Molecular function	integrin binding : IDA:MGI signaling receptor activity : TAS:ProtInc transmembrane signaling receptor activity : TAS:ProtInc virus receptor activity : IEA:UniProtKB-KW
GO - Biological process	acute inflammatory response to antigenic stimulus : IEA:Ensembl adhesion of symbiont to host : IDA:BHF-UCL cell adhesion : IDA:BHF-UCL cell adhesion mediated by integrin : IEA:Ensembl cell aging : IEA:Ensembl cellular response to alkaloid : IEA:Ensembl cellular response to dexamethasone stimulus : IEA:Ensembl cellular response to glucose stimulus : IEA:Ensembl cellular response to hypoxia : IEA:Ensembl cellular response to interleukin-1 : IEA:Ensembl cellular response to interleukin-6 : IEA:Ensembl cellular response to leukemia inhibitory factor : IEA:Ensembl cellular response to lipopolysaccharide : IEA:Ensembl cellular response to nutrient levels : IEA:Ensembl cellular response to tumor necrosis factor : IEA:Ensembl cytokine-mediated signaling pathway : TAS:Reactome establishment of endothelial barrier : IGI:UniProtKB establishment of endothelial intestinal barrier : IEA:Ensembl establishment of Sertoli cell barrier : IEA:Ensembl extracellular matrix organization : TAS:Reactome heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : TAS:BHF-UCL interferon-gamma-mediated signaling pathway : TAS:Reactome leukocyte cell-cell adhesion : IMP:BHF-UCL leukocyte migration : IEP:BHF-UCL membrane to membrane docking : IEP:BHF-UCL negative regulation of calcium ion transport : IEA:Ensembl negative regulation of endothelial cell apoptotic process : IDA:BHF-UCL negative regulation of extrinsic apoptotic signaling pathway via death domain receptors : IDA:BHF-UCL ovarian follicle development : IEA:Ensembl positive regulation of actin filament polymerization : IEA:Ensembl positive regulation of cellular extravasation : IMP:BHF-UCL positive regulation of ERK1 and ERK2 cascade : IMP:BHF-UCL positive regulation of GTPase activity : IEA:Ensembl positive regulation of leukocyte adhesion to vascular endothelial cell : IEA:Ensembl positive regulation of NF-kappaB transcription factor activity : IEA:Ensembl positive regulation of nitric oxide biosynthetic process : IEA:Ensembl positive regulation of peptidyl-tyrosine phosphorylation : IEA:Ensembl positive regulation of vasoconstriction : IEA:Ensembl receptor-mediated virion attachment to host cell : IDA:BHF-UCL regulation of cell shape : IEA:Ensembl regulation of immune response : TAS:Reactome regulation of leukocyte mediated cytotoxicity : TAS:BHF-UCL regulation of ruffle assembly : IEA:Ensembl response to amino acid : IEA:Ensembl response to amphetamine : IEA:Ensembl response to copper ion : IEA:Ensembl response to ethanol : IEA:Ensembl response to gonadotropin : IEA:Ensembl response to insulin : IEA:Ensembl response to ionizing radiation : IEA:Ensembl response to sulfur dioxide : IEA:Ensembl sensory perception of sound : IEA:Ensembl T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell : IMP:BHF-UCL T cell antigen processing and presentation : IEA:Ensembl T cell extravasation : IEA:Ensembl

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}