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139952

Sodium/potassium-transporting ATPase subunit alpha-1 (P05023)

Uniprot ID P05023
Protein Name Sodium/potassium-transporting ATPase subunit alpha-1
Gene Name ATP1A1
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
GO - Molecular function
  • ADP binding : IEA:Ensembl
  • ankyrin binding : IEA:Ensembl
  • ATP binding : ISS:BHF-UCL
  • chaperone binding : IPI:BHF-UCL
  • phosphatase activity : IEA:Ensembl
  • phosphatidylinositol 3-kinase binding : IEA:Ensembl
  • potassium ion binding : ISS:BHF-UCL
  • protein domain specific binding : IEA:Ensembl
  • protein kinase binding : IEA:Ensembl
  • sodium ion binding : ISS:BHF-UCL
  • sodium : IDA:BHF-UCL
  • steroid hormone binding : IDA:BHF-UCL
GO - Biological process
  • cardiac muscle cell action potential involved in contraction : TAS:BHF-UCL
  • cell communication by electrical coupling involved in cardiac conduction : TAS:BHF-UCL
  • cellular potassium ion homeostasis : IDA:BHF-UCL
  • cellular response to mechanical stimulus : IEA:Ensembl
  • cellular response to steroid hormone stimulus : IDA:BHF-UCL
  • cellular sodium ion homeostasis : IDA:BHF-UCL
  • membrane hyperpolarization : IEA:Ensembl
  • membrane repolarization : IDA:BHF-UCL
  • membrane repolarization during cardiac muscle cell action potential : IC:BHF-UCL
  • negative regulation of glucocorticoid biosynthetic process : IEA:Ensembl
  • negative regulation of heart contraction : IEA:Ensembl
  • positive regulation of heart contraction : IEA:Ensembl
  • positive regulation of striated muscle contraction : IEA:Ensembl
  • potassium ion import : IDA:BHF-UCL
  • potassium ion import across plasma membrane : ISS:BHF-UCL
  • regulation of blood pressure : IEA:Ensembl
  • regulation of cardiac muscle cell contraction : IEA:Ensembl
  • regulation of sodium ion transport : ISS:UniProtKB
  • regulation of the force of heart contraction : IEA:Ensembl
  • relaxation of cardiac muscle : TAS:BHF-UCL
  • response to drug : IEA:Ensembl
  • response to glycoside : IDA:BHF-UCL
  • sodium ion export across plasma membrane : IDA:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.