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139951

Tubulin beta-4A chain (P04350)

Uniprot ID P04350
Protein Name Tubulin beta-4A chain
Gene Name TUBB4A
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
GO - Molecular function
  • calcium ion binding : IMP:CAFA
  • GTP binding : IBA:GO_Central
  • GTPase activity : IEA:InterPro
  • structural constituent of cytoskeleton : IBA:GO_Central
GO - Biological process
  • ciliary basal body-plasma membrane docking : TAS:Reactome
  • G2/M transition of mitotic cell cycle : TAS:Reactome
  • microtubule cytoskeleton organization : IBA:GO_Central
  • microtubule-based process : IBA:GO_Central
  • mitotic cell cycle : IBA:GO_Central
  • negative regulation of microtubule polymerization : IMP:CAFA
  • regulation of G2/M transition of mitotic cell cycle : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.