| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. . |
| GO - Molecular function |
- calcium ion binding : TAS:ProtInc
- calcium-dependent protein binding : IDA:UniProtKB
- identical protein binding : IPI:IntAct
- protein homodimerization activity : IDA:UniProtKB
- RAGE receptor binding : IPI:UniProtKB
- S100 protein binding : IPI:UniProtKB
- tau protein binding : ISS:UniProtKB
- zinc ion binding : ISS:UniProtKB
|
| GO - Biological process |
- astrocyte differentiation : IEA:Ensembl
- axonogenesis : TAS:ProtInc
- cellular response to hypoxia : IEA:Ensembl
- central nervous system development : TAS:ProtInc
- innate immune response : TAS:Reactome
- learning or memory : ISS:UniProtKB
- long-term synaptic potentiation : IEA:Ensembl
- memory : IEA:Ensembl
- negative regulation of skeletal muscle cell differentiation : IEA:Ensembl
- positive regulation of apoptotic process : IEA:Ensembl
- positive regulation of cell population proliferation : IEA:Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling : IDA:UniProtKB
- positive regulation of myelination : IEA:Ensembl
- regulation of cell shape : IEA:Ensembl
- regulation of neuronal synaptic plasticity : IEA:Ensembl
- response to glucocorticoid : IEA:Ensembl
- response to methylmercury : IEA:Ensembl
|