Thy-1 membrane glycoprotein (P04216)

Uniprot ID P04216
Protein Name Thy-1 membrane glycoprotein
Gene Name THY1
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b)
Function May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
GO - Molecular function
  • GPI anchor binding : ISS:UniProtKB
  • GTPase activator activity : ISS:UniProtKB
  • integrin binding : IMP:UniProtKB
  • protein kinase binding : IBA:GO_Central
GO - Biological process
  • angiogenesis : ISS:UniProtKB
  • cell-cell adhesion : ISS:UniProtKB
  • cell-cell signaling : ISS:UniProtKB
  • cytoskeleton organization : ISS:UniProtKB
  • focal adhesion assembly : ISS:UniProtKB
  • integrin-mediated signaling pathway : IMP:UniProtKB
  • negative regulation of axonogenesis : ISS:UniProtKB
  • negative regulation of cell migration : ISS:UniProtKB
  • negative regulation of neuron projection regeneration : ISS:UniProtKB
  • negative regulation of protein kinase activity : ISS:UniProtKB
  • negative regulation of protein tyrosine kinase activity : ISS:UniProtKB
  • negative regulation of T cell receptor signaling pathway : ISS:UniProtKB
  • positive regulation of cellular extravasation : IDA:UniProtKB
  • positive regulation of focal adhesion assembly : IMP:UniProtKB
  • positive regulation of GTPase activity : ISS:UniProtKB
  • positive regulation of heterotypic cell-cell adhesion : IDA:UniProtKB
  • positive regulation of release of sequestered calcium ion into cytosol : ISS:UniProtKB
  • positive regulation of T cell activation : ISS:UniProtKB
  • protein autophosphorylation : IEA:Ensembl
  • receptor clustering : ISS:UniProtKB
  • regulation of cell-matrix adhesion : IMP:UniProtKB
  • regulation of Rho-dependent protein serine/threonine kinase activity : ISS:UniProtKB
  • retinal cone cell development : ISS:UniProtKB
  • T cell receptor signaling pathway : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.