| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. |
| GO - Molecular function |
- coenzyme binding : IDA:UniProtKB
- hydroxymethylglutaryl-CoA reductase (NADPH) activity : IBA:GO_Central
- hydroxymethylglutaryl-CoA reductase activity : IDA:UniProtKB
- NADPH binding : IDA:UniProtKB
- protein homodimerization activity : IEA:Ensembl
- protein phosphatase 2A binding : IEA:Ensembl
|
| GO - Biological process |
- aging : IEA:Ensembl
- cholesterol biosynthetic process : IDA:CACAO
- coenzyme A metabolic process : IEA:InterPro
- isoprenoid biosynthetic process : IBA:GO_Central
- myoblast differentiation : IEA:Ensembl
- negative regulation of blood vessel diameter : IEA:Ensembl
- negative regulation of insulin secretion involved in cellular response to glucose stimulus : IEA:Ensembl
- negative regulation of MAP kinase activity : IEA:Ensembl
- negative regulation of striated muscle cell apoptotic process : IEA:Ensembl
- negative regulation of wound healing : IEA:Ensembl
- positive regulation of cardiac muscle cell apoptotic process : IEA:Ensembl
- positive regulation of ERK1 and ERK2 cascade : IEA:Ensembl
- positive regulation of skeletal muscle tissue development : IEA:Ensembl
- positive regulation of smooth muscle cell proliferation : IEA:Ensembl
- positive regulation of stress-activated MAPK cascade : IEA:Ensembl
- protein tetramerization : IDA:UniProtKB
- regulation of cholesterol biosynthetic process : TAS:Reactome
- regulation of lipid metabolic process : TAS:Reactome
- response to ethanol : IEA:Ensembl
- response to nutrient : IEA:Ensembl
- ubiquinone metabolic process : IEA:Ensembl
- visual learning : IEA:Ensembl
|