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139946

Platelet factor 4 (P02776)

Uniprot ID P02776
Protein Name Platelet factor 4
Gene Name PF4
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. .
GO - Molecular function
  • chemokine activity : TAS:UniProtKB
  • CXCR3 chemokine receptor binding : IDA:UniProtKB
  • heparin binding : IDA:UniProtKB
GO - Biological process
  • antimicrobial humoral immune response mediated by antimicrobial peptide : IDA:UniProtKB
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • cytokine-mediated signaling pathway : IDA:UniProtKB
  • defense response to protozoan : IDA:UniProtKB
  • G-protein coupled receptor signaling pathway : IBA:GO_Central
  • immune response : IBA:GO_Central
  • inflammatory response : IBA:GO_Central
  • killing by host of symbiont cells : IDA:UniProtKB
  • killing of cells of other organism : IDA:UniProtKB
  • leukocyte chemotaxis : IDA:UniProtKB
  • negative regulation of angiogenesis : IDA:UniProtKB
  • negative regulation of cytolysis : IDA:BHF-UCL
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : IDA:BHF-UCL
  • negative regulation of megakaryocyte differentiation : IDA:UniProtKB
  • negative regulation of MHC class II biosynthetic process : IDA:BHF-UCL
  • platelet activation : IDA:UniProtKB
  • platelet degranulation : TAS:Reactome
  • positive regulation of cAMP metabolic process : IDA:UniProtKB
  • positive regulation of cAMP-mediated signaling : IDA:UniProtKB
  • positive regulation of gene expression : IDA:BHF-UCL
  • positive regulation of macrophage derived foam cell differentiation : IDA:BHF-UCL
  • positive regulation of macrophage differentiation : IDA:BHF-UCL
  • positive regulation of neutrophil chemotaxis : IBA:GO_Central
  • positive regulation of transcription by RNA polymerase II : IDA:UniProtKB
  • positive regulation of tumor necrosis factor production : IDA:BHF-UCL
  • regulation of cell proliferation : IDA:UniProtKB
  • regulation of megakaryocyte differentiation : TAS:Reactome
  • response to lipopolysaccharide : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.