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139943

Complement C1q subcomponent subunit A (P02745)

Uniprot ID P02745
Protein Name Complement C1q subcomponent subunit A
Gene Name C1QA
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
GO - Molecular function
  • serine-type endopeptidase activity : TAS:Reactome
GO - Biological process
  • cell-cell signaling : TAS:ProtInc
  • complement activation : TAS:Reactome
  • complement activation, classical pathway : TAS:Reactome
  • innate immune response : IEA:UniProtKB-KW
  • regulation of complement activation : TAS:Reactome
  • response to iron ion : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.