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139942

Collagen alpha-1(IV) chain (P02462)

Uniprot ID P02462
Protein Name Collagen alpha-1(IV) chain
Gene Name COL4A1
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. .Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin. {ECO:0000269|PubMed:10811134, ECO:0000269|PubMed:16151532, ECO:0000269|PubMed:18775695}.
GO - Molecular function
  • extracellular matrix constituent conferring elasticity : IC:BHF-UCL
  • extracellular matrix structural constituent : IMP:BHF-UCL
  • platelet-derived growth factor binding : IDA:MGI
GO - Biological process
  • basement membrane organization : IMP:BHF-UCL
  • blood vessel morphogenesis : IMP:BHF-UCL
  • brain development : IMP:BHF-UCL
  • branching involved in blood vessel morphogenesis : IMP:BHF-UCL
  • cellular response to amino acid stimulus : IEA:Ensembl
  • collagen-activated tyrosine kinase receptor signaling pathway : IEA:Ensembl
  • epithelial cell differentiation : IEA:Ensembl
  • extracellular matrix organization : TAS:Reactome
  • neuromuscular junction development : IEA:Ensembl
  • renal tubule morphogenesis : IMP:BHF-UCL
  • retinal blood vessel morphogenesis : IMP:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.