| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Met-and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. |
| GO - Molecular function |
- neuropeptide hormone activity : TAS:ProtInc
- opioid peptide activity : IEA:UniProtKB-KW
- opioid receptor binding : IBA:GO_Central
|
| GO - Biological process |
- aggressive behavior : IEA:Ensembl
- aging : IEA:Ensembl
- behavioral fear response : IEA:Ensembl
- cellular protein metabolic process : TAS:Reactome
- cellular response to cAMP : IEA:Ensembl
- cellular response to oxidative stress : IEA:Ensembl
- cellular response to transforming growth factor beta stimulus : IEA:Ensembl
- cellular response to virus : IEA:Ensembl
- cellular response to vitamin D : IEA:Ensembl
- chemical synaptic transmission : IBA:GO_Central
- G protein-coupled receptor signaling pathway : TAS:Reactome
- general adaptation syndrome, behavioral process : IEA:Ensembl
- glial cell proliferation : IEA:Ensembl
- locomotory exploration behavior : IEA:Ensembl
- neuropeptide signaling pathway : IBA:GO_Central
- osteoblast differentiation : IEA:Ensembl
- positive regulation of behavioral fear response : IEA:Ensembl
- post-translational protein modification : TAS:Reactome
- response to calcium ion : IEA:Ensembl
- response to epinephrine : IEA:Ensembl
- response to estradiol : IEA:Ensembl
- response to ethanol : IEA:Ensembl
- response to hypoxia : IEA:Ensembl
- response to lipopolysaccharide : IEA:Ensembl
- response to morphine : IEA:Ensembl
- response to nicotine : IEA:Ensembl
- response to radiation : IEA:Ensembl
- sensory perception : IBA:GO_Central
- sensory perception of pain : IEA:Ensembl
- signal transduction : TAS:ProtInc
- startle response : IEA:Ensembl
- synaptic signaling via neuropeptide : IEA:Ensembl
|