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139939

Urokinase-type plasminogen activator (P00749)

Uniprot ID P00749
Protein Name Urokinase-type plasminogen activator
Gene Name PLAU
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
GO - Molecular function
  • serine-type endopeptidase activity : IBA:GO_Central
GO - Biological process
  • blood coagulation : IEA:UniProtKB-KW
  • chemotaxis : TAS:ProtInc
  • fibrinolysis : TAS:Reactome
  • neutrophil degranulation : TAS:Reactome
  • plasminogen activation : IDA:AgBase
  • positive regulation of cell migration : IDA:MGI
  • proteolysis : TAS:ProtInc
  • regulation of cell adhesion mediated by integrin : IDA:BHF-UCL
  • regulation of cell proliferation : IEA:Ensembl
  • regulation of signaling receptor activity : IDA:BHF-UCL
  • regulation of smooth muscle cell migration : IDA:BHF-UCL
  • regulation of smooth muscle cell-matrix adhesion : IDA:BHF-UCL
  • regulation of wound healing : IC:BHF-UCL
  • response to hypoxia : IEA:Ensembl
  • signal transduction : TAS:ProtInc
  • smooth muscle cell migration : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.