Aspartate aminotransferase, mitochondrial (P00505)

Uniprot ID P00505
Protein Name Aspartate aminotransferase, mitochondrial
Gene Name GOT2
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. .
GO - Molecular function
  • 4-hydroxyglutamate transaminase activity : TAS:Reactome
  • amino acid binding : IEA:Ensembl
  • enzyme binding : IEA:Ensembl
  • kynurenine-oxoglutarate transaminase activity : IEA:UniProtKB-EC
  • L-aspartate : IDA:UniProtKB
  • phospholipid binding : IEA:Ensembl
  • protein homodimerization activity : IEA:Ensembl
  • pyridoxal phosphate binding : IEA:Ensembl
  • RNA binding : HDA:UniProtKB
GO - Biological process
  • 2-oxoglutarate metabolic process : ISS:UniProtKB
  • 4-hydroxyproline catabolic process : TAS:BHF-UCL
  • aspartate biosynthetic process : IEA:Ensembl
  • aspartate catabolic process : IDA:UniProtKB
  • aspartate metabolic process : ISS:UniProtKB
  • cellular amino acid biosynthetic process : TAS:Reactome
  • fatty acid transport : IEP:UniProtKB
  • female pregnancy : IEA:Ensembl
  • gluconeogenesis : TAS:Reactome
  • glutamate catabolic process to 2-oxoglutarate : IEA:Ensembl
  • glutamate catabolic process to aspartate : IEA:Ensembl
  • glutamate metabolic process : ISS:UniProtKB
  • glyoxylate metabolic process : TAS:Reactome
  • lactation : IEA:Ensembl
  • oxaloacetate metabolic process : IEA:Ensembl
  • response to ethanol : IDA:UniProtKB
  • response to insulin : IEA:Ensembl
  • response to morphine : IEA:Ensembl
  • response to muscle activity : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.