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139936

Ceruloplasmin (P00450)

Uniprot ID P00450
Protein Name Ceruloplasmin
Gene Name CP
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). .
GO - Molecular function
  • chaperone binding : IPI:BHF-UCL
  • copper ion binding : IEA:InterPro
  • ferroxidase activity : TAS:Reactome
GO - Biological process
  • cellular iron ion homeostasis : TAS:Reactome
  • cellular protein metabolic process : TAS:Reactome
  • copper ion transport : IEA:UniProtKB-KW
  • post-translational protein modification : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.