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139935

Dihydrofolate reductase (P00374)

Uniprot ID P00374
Protein Name Dihydrofolate reductase
Gene Name DHFR
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. .
GO - Molecular function
  • dihydrofolate reductase activity : IDA:UniProtKB
  • drug binding : IDA:UniProtKB
  • folate reductase activity : TAS:Reactome
  • folic acid binding : IDA:BHF-UCL
  • methotrexate binding : IDA:BHF-UCL
  • mRNA binding : IDA:UniProtKB
  • NADPH binding : IDA:BHF-UCL
  • sequence-specific mRNA binding : IDA:CAFA
  • translation repressor activity, mRNA regulatory element binding : IDA:CAFA
GO - Biological process
  • axon regeneration : ISS:BHF-UCL
  • dihydrofolate metabolic process : IDA:BHF-UCL
  • folic acid metabolic process : ISS:BHF-UCL
  • negative regulation of translation : IDA:CAFA
  • one-carbon metabolic process : IEA:UniProtKB-KW
  • oxidation-reduction process : IDA:BHF-UCL
  • positive regulation of nitric-oxide synthase activity : ISS:BHF-UCL
  • regulation of removal of superoxide radicals : ISS:BHF-UCL
  • regulation of transcription involved in G1/S transition of mitotic cell cycle : TAS:Reactome
  • response to methotrexate : ISS:BHF-UCL
  • tetrahydrobiopterin biosynthetic process : IMP:BHF-UCL
  • tetrahydrofolate biosynthetic process : IDA:BHF-UCL
  • tetrahydrofolate metabolic process : IDA:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.