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139934

Geranylgeranyl pyrophosphate synthase (O95749)

Uniprot ID O95749
Protein Name Geranylgeranyl pyrophosphate synthase
Gene Name GGPS1
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
GO - Molecular function
  • dimethylallyltranstransferase activity : IEA:UniProtKB-EC
  • farnesyltranstransferase activity : IDA:UniProtKB
  • geranyltranstransferase activity : IEA:UniProtKB-EC
  • identical protein binding : IPI:IntAct
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • cholesterol biosynthetic process : TAS:Reactome
  • farnesyl diphosphate biosynthetic process : IEA:UniProtKB-UniPathway
  • geranyl diphosphate biosynthetic process : IEA:UniProtKB-UniPathway
  • geranylgeranyl diphosphate biosynthetic process : IEA:UniProtKB-UniPathway
  • isoprenoid metabolic process : IDA:UniProtKB
  • regulation of cholesterol biosynthetic process : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.