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139932

Metastasis-associated protein MTA2 (O94776)

Uniprot ID O94776
Protein Name Metastasis-associated protein MTA2
Gene Name MTA2
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
GO - Molecular function
  • chromatin binding : IEA:InterPro
  • histone deacetylase activity : IEA:Ensembl
  • histone deacetylase binding : IBA:GO_Central
  • RNA polymerase II repressing transcription factor binding : IPI:BHF-UCL
  • RNA polymerase II transcription factor binding : IPI:BHF-UCL
  • sequence-specific DNA binding : IEA:InterPro
  • transcription coactivator activity : IBA:GO_Central
  • transcription corepressor activity : IBA:GO_Central
  • transcription regulatory region DNA binding : IEA:Ensembl
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • ATP-dependent chromatin remodeling : HDA:UniProtKB
  • chromatin assembly or disassembly : TAS:ProtInc
  • DNA methylation : IEA:Ensembl
  • histone deacetylation : IBA:GO_Central
  • negative regulation of transcription by RNA polymerase II : IBA:GO_Central
  • positive regulation of transcription by RNA polymerase II : IEA:Ensembl
  • regulation of fibroblast migration : IEA:Ensembl
  • regulation of signal transduction by p53 class mediator : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.