Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
139929

Ceroid-lipofuscinosis neuronal protein 5 (O75503)

Uniprot ID O75503
Protein Name Ceroid-lipofuscinosis neuronal protein 5
Gene Name CLN5
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521). .
GO - Molecular function
  • mannose binding : IDA:UniProtKB
GO - Biological process
  • brain development : IEP:UniProtKB
  • glycosylation : IDA:UniProtKB
  • lysosomal lumen acidification : IMP:UniProtKB
  • neurogenesis : IEP:UniProtKB
  • neuron maturation : NAS:UniProtKB
  • positive regulation of GTP binding : IMP:UniProtKB
  • protein catabolic process : NAS:UniProtKB
  • retrograde transport, endosome to Golgi : IMP:UniProtKB
  • signal peptide processing : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.