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139928

Carbohydrate sulfotransferase 1 (O43916)

Uniprot ID O43916
Protein Name Carbohydrate sulfotransferase 1
Gene Name CHST1
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. .
GO - Molecular function
  • keratan sulfotransferase activity : IDA:UniProtKB
  • N-acetylglucosamine 6-O-sulfotransferase activity : IBA:GO_Central
  • sulfotransferase activity : IDA:UniProtKB
GO - Biological process
  • galactose metabolic process : IDA:UniProtKB
  • inflammatory response : IEA:UniProtKB-KW
  • keratan sulfate biosynthetic process : TAS:Reactome
  • keratan sulfate metabolic process : IDA:UniProtKB
  • N-acetylglucosamine metabolic process : IBA:GO_Central
  • polysaccharide metabolic process : TAS:ProtInc
  • sulfur compound metabolic process : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.