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11258

Extracellular matrix protein 1 (Q16610)

Uniprot ID Q16610
Protein Name Extracellular matrix protein 1
Gene Name ECM1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.729
Function Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. .
GO - Molecular function
  • enzyme binding : IPI:UniProtKB
  • interleukin-2 receptor binding : IEA:Ensembl
  • laminin binding : IPI:UniProtKB
  • protease binding : IPI:UniProtKB
  • protein C-terminus binding : IPI:UniProtKB
GO - Biological process
  • angiogenesis : IEA:UniProtKB-KW
  • biomineral tissue development : IEA:UniProtKB-KW
  • inflammatory response : IEA:Ensembl
  • negative regulation of bone mineralization : IDA:UniProtKB
  • negative regulation of cytokine-mediated signaling pathway : IEA:Ensembl
  • negative regulation of peptidase activity : IDA:UniProtKB
  • ossification : IEA:UniProtKB-KW
  • platelet degranulation : TAS:Reactome
  • positive regulation of angiogenesis : IDA:UniProtKB
  • positive regulation of endothelial cell proliferation : IDA:UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling : HMP:UniProtKB
  • regulation of T cell migration : IEA:Ensembl
  • regulation of transcription by RNA polymerase II : IEA:Ensembl
  • regulation of type 2 immune response : IEA:Ensembl
  • signal transduction : IEA:InterPro
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.