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11153

Lactoylglutathione lyase (Q04760)

Uniprot ID Q04760
Protein Name Lactoylglutathione lyase
Gene Name GLO1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.695
Function Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. .
GO - Molecular function
  • lactoylglutathione lyase activity : IDA:UniProtKB
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • carbohydrate metabolic process : NAS:ProtInc
  • glutathione metabolic process : IEA:Ensembl
  • methylglyoxal metabolic process : IEA:Ensembl
  • negative regulation of apoptotic process : IDA:UniProtKB
  • osteoclast differentiation : ISS:UniProtKB
  • pyruvate metabolic process : TAS:Reactome
  • regulation of transcription by RNA polymerase II : IEA:Ensembl
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.