| Signal peptide(a) |
N |
Secretome P(b) |
0.13 |
| Function |
Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. .[Non-collagenous domain 1]: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling. {ECO:0000269|PubMed:11257123}.Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis (PubMed:9459295). May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123). {ECO:0000250|UniProtKB:P39061, ECO:0000269|PubMed:11257123, ECO:0000269|PubMed:9459295}. |
| GO - Molecular function |
- extracellular matrix structural constituent : IBA:GO_Central
- identical protein binding : IPI:IntAct
- metal ion binding : IEA:UniProtKB-KW
|
| GO - Biological process |
- angiogenesis : IBA:GO_Central
- animal organ morphogenesis : TAS:ProtInc
- cell adhesion : IEA:UniProtKB-KW
- endothelial cell morphogenesis : IBA:GO_Central
- extracellular matrix organization : IBA:GO_Central
- negative regulation of cell population proliferation : TAS:ProtInc
- positive regulation of cell migration : IEA:Ensembl
- positive regulation of cell population proliferation : IEA:Ensembl
- positive regulation of endothelial cell apoptotic process : IEA:Ensembl
- response to drug : IEA:Ensembl
- response to hydrostatic pressure : IEA:Ensembl
- visual perception : TAS:ProtInc
|