Signal peptide(a) |
Y |
Secretome P(b) |
0.217 |
Function |
Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. . |
GO - Molecular function |
- copper ion binding : IDA:UniProtKB
- fibroblast growth factor binding : ISS:UniProtKB
- heparan sulfate proteoglycan binding : IEA:InterPro
- laminin binding : ISS:UniProtKB
|
GO - Biological process |
- axon guidance : TAS:Reactome
- glycosaminoglycan biosynthetic process : TAS:Reactome
- glycosaminoglycan catabolic process : TAS:Reactome
- heparan sulfate proteoglycan catabolic process : IDA:UniProtKB
- leukocyte migration : TAS:Reactome
- myelin assembly : ISS:UniProtKB
- negative regulation of fibroblast growth factor receptor signaling pathway : ISS:UniProtKB
- positive regulation of skeletal muscle cell differentiation : ISS:UniProtKB
- retinoid metabolic process : TAS:Reactome
- Schwann cell differentiation : ISS:UniProtKB
|