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10727

Peroxiredoxin-2 (P32119)

Uniprot ID P32119
Protein Name Peroxiredoxin-2
Gene Name PRDX2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.825
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). .
GO - Molecular function
  • antioxidant activity : IDA:UniProtKB
  • thioredoxin peroxidase activity : IDA:UniProtKB
GO - Biological process
  • cell redox homeostasis : IEA:InterPro
  • cellular response to oxidative stress : IDA:BHF-UCL
  • hydrogen peroxide catabolic process : TAS:BHF-UCL
  • negative regulation of apoptotic process : TAS:UniProtKB
  • regulation of apoptotic process : IMP:UniProtKB
  • removal of superoxide radicals : IDA:BHF-UCL
  • response to oxidative stress : IMP:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.