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10718

Adenylosuccinate synthetase isozyme 2 (P30520)

Uniprot ID P30520
Protein Name Adenylosuccinate synthetase isozyme 2
Gene Name ADSS
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.634
Function Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
GO - Molecular function
  • adenylosuccinate synthase activity : IDA:UniProtKB
  • GTP binding : NAS:UniProtKB
  • metal ion binding : IEA:UniProtKB-KW
  • phosphate ion binding : NAS:UniProtKB
GO - Biological process
  • 'de novo' AMP biosynthetic process : IBA:GO_Central
  • AMP biosynthetic process : IDA:UniProtKB
  • aspartate metabolic process : IEA:Ensembl
  • cellular response to electrical stimulus : IEA:Ensembl
  • immune system process : NAS:UniProtKB
  • IMP metabolic process : IBA:GO_Central
  • purine ribonucleoside monophosphate biosynthetic process : TAS:Reactome
  • response to ammonium ion : IEA:Ensembl
  • response to purine-containing compound : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.