Phosphatidylethanolamine-binding protein 1 (P30086)

Uniprot ID P30086
Protein Name Phosphatidylethanolamine-binding protein 1
Gene Name PEBP1
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.897
Function Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. .HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • enzyme binding : IPI:UniProtKB
  • phosphatidylethanolamine binding : TAS:ProtInc
  • protein kinase binding : IPI:UniProtKB
  • RNA binding : HDA:UniProtKB
  • serine-type endopeptidase inhibitor activity : IEA:UniProtKB-KW
GO - Biological process
  • MAPK cascade : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.