| Signal peptide(a) |
N |
Secretome P(b) |
0.743 |
| Function |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. . |
| GO - Molecular function |
- cadherin binding : HDA:BHF-UCL
- calcium-independent phospholipase A2 activity : IMP:CAFA
- glutathione peroxidase activity : IMP:CAFA
- identical protein binding : IMP:CAFA
- peroxiredoxin activity : IEA:UniProtKB-EC
- phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) : IEA:UniProtKB-EC
- phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) : IEA:UniProtKB-EC
- ubiquitin protein ligase binding : IPI:ParkinsonsUK-UCL
|
| GO - Biological process |
- cell redox homeostasis : IBA:GO_Central
- cellular oxidant detoxification : IMP:CAFA
- cellular response to oxidative stress : TAS:Reactome
- glycerophospholipid catabolic process : IMP:CAFA
- hydrogen peroxide catabolic process : IEA:Ensembl
- neutrophil degranulation : TAS:Reactome
- positive regulation of mRNA splicing, via spliceosome : IGI:UniProtKB
- response to oxidative stress : IMP:CAFA
|