| Signal peptide(a) |
Y |
Secretome P(b) |
0.736 |
| Function |
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin-and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. . |
| GO - Molecular function |
- fibronectin binding : IEA:Ensembl
- growth factor activity : IEA:Ensembl
- heparin binding : IBA:GO_Central
- insulin-like growth factor binding : TAS:ProtInc
- integrin binding : IBA:GO_Central
- protein C-terminus binding : IPI:UniProtKB
|
| GO - Biological process |
- aging : IEA:Ensembl
- angiogenesis : IEA:Ensembl
- cartilage condensation : IEA:Ensembl
- cell adhesion : IBA:GO_Central
- cell differentiation : IEA:Ensembl
- cell migration : IEA:Ensembl
- cell-cell signaling : IBA:GO_Central
- cell-matrix adhesion : IEA:Ensembl
- chondrocyte proliferation : IEA:Ensembl
- cytosolic calcium ion transport : IEA:Ensembl
- DNA biosynthetic process : IEA:UniProtKB-KW
- epidermis development : TAS:ProtInc
- extracellular matrix constituent secretion : IEA:Ensembl
- fibroblast growth factor receptor signaling pathway : IEA:Ensembl
- integrin-mediated signaling pathway : IEA:Ensembl
- intracellular signal transduction : IEA:Ensembl
- lung development : IEA:Ensembl
- negative regulation of cell death : IBA:GO_Central
- negative regulation of gene expression : IEA:Ensembl
- ossification : IEA:Ensembl
- positive regulation of cardiac muscle contraction : IEA:Ensembl
- positive regulation of cell activation : IEA:Ensembl
- positive regulation of cell differentiation : IDA:BHF-UCL
- positive regulation of cell proliferation : IEA:Ensembl
- positive regulation of collagen biosynthetic process : IEA:Ensembl
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process : IEA:Ensembl
- positive regulation of ERK1 and ERK2 cascade : IDA:BHF-UCL
- positive regulation of G0 to G1 transition : IEA:Ensembl
- positive regulation of gene expression : IEA:Ensembl
- positive regulation of JNK cascade : IDA:BHF-UCL
- positive regulation of stress fiber assembly : IDA:BHF-UCL
- reactive oxygen species metabolic process : IEA:Ensembl
- regulation of cell growth : IEA:InterPro
- regulation of chondrocyte differentiation : IEA:Ensembl
- response to amino acid : IEA:Ensembl
- response to anoxia : IEA:Ensembl
- response to estradiol : IEA:Ensembl
- response to fatty acid : IEA:Ensembl
- response to glucose : IEA:Ensembl
- response to mineralocorticoid : IEA:Ensembl
- response to peptide hormone : IEA:Ensembl
- response to wounding : TAS:ProtInc
- tissue homeostasis : IEA:Ensembl
- transcription initiation from RNA polymerase II promoter : TAS:Reactome
|