Signal peptide(a) |
Y |
Secretome P(b) |
0.457 |
Function |
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. . |
GO - Molecular function |
- collagen binding : TAS:UniProtKB
- endopeptidase activity : IDA:ParkinsonsUK-UCL
- identical protein binding : IPI:IntAct
- metalloendopeptidase activity : IDA:UniProtKB
- metallopeptidase activity : IDA:UniProtKB
- serine-type endopeptidase activity : EXP:Reactome
- zinc ion binding : TAS:UniProtKB
|
GO - Biological process |
- cellular response to cadmium ion : IDA:CAFA
- cellular response to reactive oxygen species : IDA:CAFA
- collagen catabolic process : TAS:Reactome
- cytokine-mediated signaling pathway : TAS:Reactome
- embryo implantation : IEA:Ensembl
- endodermal cell differentiation : IEP:UniProtKB
- ephrin receptor signaling pathway : TAS:Reactome
- extracellular matrix disassembly : TAS:Reactome
- leukocyte migration : IEA:InterPro
- macrophage differentiation : TAS:UniProtKB
- negative regulation of apoptotic process : IMP:CACAO
- negative regulation of cation channel activity : IDA:UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway : IMP:CACAO
- negative regulation of intrinsic apoptotic signaling pathway : IMP:CACAO
- neutrophil degranulation : TAS:Reactome
- ossification : IEA:InterPro
- positive regulation of cell migration : TAS:ParkinsonsUK-UCL
- positive regulation of DNA binding : IDA:CACAO
- positive regulation of epidermal growth factor receptor signaling pathway : IMP:CACAO
- positive regulation of keratinocyte migration : IMP:BHF-UCL
- positive regulation of protein phosphorylation : IMP:CACAO
- positive regulation of receptor binding : IDA:UniProtKB
- positive regulation of release of cytochrome c from mitochondria : IMP:CACAO
- positive regulation of vascular smooth muscle cell proliferation : IMP:BHF-UCL
- proteolysis : IDA:UniProtKB
- skeletal system development : IEA:Ensembl
|