Matrix metalloproteinase-9 (P14780)

Uniprot ID P14780
Protein Name Matrix metalloproteinase-9
Gene Name MMP9
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.457
Function May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. .
GO - Molecular function
  • collagen binding : TAS:UniProtKB
  • endopeptidase activity : IDA:ParkinsonsUK-UCL
  • identical protein binding : IPI:IntAct
  • metalloendopeptidase activity : IDA:UniProtKB
  • metallopeptidase activity : IDA:UniProtKB
  • serine-type endopeptidase activity : EXP:Reactome
  • zinc ion binding : TAS:UniProtKB
GO - Biological process
  • cellular response to cadmium ion : IDA:CAFA
  • cellular response to reactive oxygen species : IDA:CAFA
  • collagen catabolic process : TAS:Reactome
  • cytokine-mediated signaling pathway : TAS:Reactome
  • embryo implantation : IEA:Ensembl
  • endodermal cell differentiation : IEP:UniProtKB
  • ephrin receptor signaling pathway : TAS:Reactome
  • extracellular matrix disassembly : TAS:Reactome
  • leukocyte migration : IEA:InterPro
  • macrophage differentiation : TAS:UniProtKB
  • negative regulation of apoptotic process : IMP:CACAO
  • negative regulation of cation channel activity : IDA:UniProtKB
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway : IMP:CACAO
  • negative regulation of intrinsic apoptotic signaling pathway : IMP:CACAO
  • neutrophil degranulation : TAS:Reactome
  • ossification : IEA:InterPro
  • positive regulation of cell migration : TAS:ParkinsonsUK-UCL
  • positive regulation of DNA binding : IDA:CACAO
  • positive regulation of epidermal growth factor receptor signaling pathway : IMP:CACAO
  • positive regulation of keratinocyte migration : IMP:BHF-UCL
  • positive regulation of protein phosphorylation : IMP:CACAO
  • positive regulation of receptor binding : IDA:UniProtKB
  • positive regulation of release of cytochrome c from mitochondria : IMP:CACAO
  • positive regulation of vascular smooth muscle cell proliferation : IMP:BHF-UCL
  • proteolysis : IDA:UniProtKB
  • skeletal system development : IEA:Ensembl
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.