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10411

Collagen alpha-2(I) chain (P08123)

Uniprot ID P08123
Protein Name Collagen alpha-2(I) chain
Gene Name COL1A2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.323
Function Type I collagen is a member of group I collagen (fibrillar forming collagen).
GO - Molecular function
  • extracellular matrix structural constituent : NAS:UniProtKB
  • identical protein binding : IDA:UniProtKB
  • metal ion binding : IEA:UniProtKB-KW
  • platelet-derived growth factor binding : IDA:MGI
  • protease binding : IPI:CAFA
  • protein binding, bridging : IMP:UniProtKB
  • SMAD binding : IEA:Ensembl
GO - Biological process
  • blood coagulation : TAS:Reactome
  • blood vessel development : IMP:UniProtKB
  • cellular response to amino acid stimulus : IEA:Ensembl
  • collagen fibril organization : IMP:UniProtKB
  • cytokine-mediated signaling pathway : TAS:Reactome
  • extracellular matrix organization : TAS:Reactome
  • leukocyte migration : TAS:Reactome
  • odontogenesis : NAS:UniProtKB
  • platelet activation : TAS:Reactome
  • protein heterotrimerization : IEA:Ensembl
  • regulation of blood pressure : IMP:UniProtKB
  • regulation of immune response : TAS:Reactome
  • Rho protein signal transduction : IDA:UniProtKB
  • skeletal system development : IMP:UniProtKB
  • skin morphogenesis : IMP:UniProtKB
  • transforming growth factor beta receptor signaling pathway : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.