| Signal peptide(a) |
Y |
Secretome P(b) |
0.501 |
| Function |
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. . |
| GO - Molecular function |
- actin binding : IDA:UniProtKB
- actin filament binding : IEA:InterPro
- calcium ion binding : IMP:UniProtKB
- myosin II binding : IPI:UniProtKB
|
| GO - Biological process |
- actin filament capping : IMP:UniProtKB
- actin filament polymerization : IDA:UniProtKB
- actin filament reorganization : IGI:UniProtKB
- actin filament severing : IDA:UniProtKB
- actin nucleation : IEA:InterPro
- aging : IEA:Ensembl
- amyloid fibril formation : IMP:UniProtKB
- barbed-end actin filament capping : TAS:ProtInc
- cellular protein metabolic process : TAS:Reactome
- cellular response to cadmium ion : IEA:Ensembl
- cellular response to interferon-gamma : IEA:Ensembl
- cilium assembly : IMP:UniProtKB
- hepatocyte apoptotic process : IMP:UniProtKB
- negative regulation of viral entry into host cell : IMP:UniProtKB
- neutrophil degranulation : TAS:Reactome
- oligodendrocyte development : IEA:Ensembl
- phagocytosis, engulfment : ISS:UniProtKB
- phosphatidylinositol-mediated signaling : IEA:Ensembl
- positive regulation of actin nucleation : IMP:UniProtKB
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway : IMP:UniProtKB
- positive regulation of gene expression : IMP:UniProtKB
- positive regulation of keratinocyte apoptotic process : IMP:UniProtKB
- positive regulation of protein processing in phagocytic vesicle : ISS:UniProtKB
- protein destabilization : IMP:UniProtKB
- regulation of cell adhesion : IEA:Ensembl
- regulation of establishment of T cell polarity : IMP:UniProtKB
- regulation of plasma membrane raft polarization : IMP:UniProtKB
- regulation of podosome assembly : IMP:UniProtKB
- regulation of receptor clustering : IMP:UniProtKB
- renal protein absorption : IMP:UniProtKB
- response to ethanol : IEA:Ensembl
- response to folic acid : IEA:Ensembl
- sequestering of actin monomers : IMP:UniProtKB
- striated muscle atrophy : IMP:UniProtKB
- tissue regeneration : IEA:Ensembl
|