Collagen alpha-1(I) chain (P02452)

Uniprot ID P02452
Protein Name Collagen alpha-1(I) chain
Gene Name COL1A1
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.201
Function Type I collagen is a member of group I collagen (fibrillar forming collagen).
GO - Molecular function
  • extracellular matrix structural constituent : IEA:Ensembl
  • identical protein binding : IDA:UniProtKB
  • metal ion binding : IEA:UniProtKB-KW
  • platelet-derived growth factor binding : IDA:MGI
  • protease binding : IPI:CAFA
GO - Biological process
  • blood coagulation : TAS:Reactome
  • blood vessel development : IMP:UniProtKB
  • bone trabecula formation : IEA:Ensembl
  • cartilage development involved in endochondral bone morphogenesis : IEA:Ensembl
  • cellular response to amino acid stimulus : IEA:Ensembl
  • cellular response to epidermal growth factor stimulus : IEA:Ensembl
  • cellular response to fibroblast growth factor stimulus : IEA:Ensembl
  • cellular response to fluoride : IEA:Ensembl
  • cellular response to mechanical stimulus : IEA:Ensembl
  • cellular response to retinoic acid : IEA:Ensembl
  • cellular response to transforming growth factor beta stimulus : IEA:Ensembl
  • cellular response to tumor necrosis factor : IEA:Ensembl
  • cellular response to vitamin E : IEA:Ensembl
  • collagen biosynthetic process : IMP:UniProtKB
  • collagen fibril organization : IMP:UniProtKB
  • collagen-activated tyrosine kinase receptor signaling pathway : IEA:Ensembl
  • embryonic skeletal system development : IMP:UniProtKB
  • endochondral ossification : IEA:Ensembl
  • extracellular matrix organization : TAS:Reactome
  • face morphogenesis : IEA:Ensembl
  • intramembranous ossification : IEA:Ensembl
  • leukocyte migration : TAS:Reactome
  • negative regulation of cell-substrate adhesion : IEA:Ensembl
  • osteoblast differentiation : IEA:Ensembl
  • platelet activation : TAS:Reactome
  • positive regulation of canonical Wnt signaling pathway : IDA:UniProtKB
  • positive regulation of cell migration : IDA:UniProtKB
  • positive regulation of epithelial to mesenchymal transition : IDA:UniProtKB
  • positive regulation of transcription, DNA-templated : IDA:UniProtKB
  • protein heterotrimerization : IEA:Ensembl
  • protein localization to nucleus : IDA:UniProtKB
  • protein transport : IEA:Ensembl
  • regulation of immune response : TAS:Reactome
  • response to cAMP : IEA:Ensembl
  • response to corticosteroid : IEA:Ensembl
  • response to estradiol : IEA:Ensembl
  • response to hydrogen peroxide : IEA:Ensembl
  • response to hyperoxia : IEA:Ensembl
  • response to peptide hormone : IEA:Ensembl
  • sensory perception of sound : IMP:UniProtKB
  • skeletal system development : IMP:UniProtKB
  • skin morphogenesis : IMP:UniProtKB
  • tooth eruption : IEA:Ensembl
  • tooth mineralization : IMP:UniProtKB
  • visual perception : IMP:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.