| Signal peptide(a) |
Y |
Secretome P(b) |
0.219 |
| Function |
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). . |
| GO - Molecular function |
- apolipoprotein binding : IBA:GO_Central
- coreceptor activity involved in canonical Wnt signaling pathway : NAS:ParkinsonsUK-UCL
- coreceptor activity involved in Wnt signaling pathway : IDA:BHF-UCL
- frizzled binding : IPI:BHF-UCL
- identical protein binding : IPI:IntAct
- kinase inhibitor activity : IMP:BHF-UCL
- low-density lipoprotein particle receptor activity : IDA:MGI
- protein homodimerization activity : IPI:BHF-UCL
- signaling receptor binding : IPI:BHF-UCL
- toxin transmembrane transporter activity : IMP:BHF-UCL
- Wnt-activated receptor activity : IBA:GO_Central
- Wnt-protein binding : IPI:BHF-UCL
|
| GO - Biological process |
- axis elongation involved in somitogenesis : IBA:GO_Central
- beta-catenin destruction complex disassembly : TAS:Reactome
- canonical Wnt signaling pathway : IDA:UniProtKB
- canonical Wnt signaling pathway involved in neural crest cell differentiation : IC:BHF-UCL
- canonical Wnt signaling pathway involved in regulation of cell proliferation : IC:BHF-UCL
- cell-cell adhesion : IEA:Ensembl
- cellular response to cholesterol : IMP:BHF-UCL
- cerebellum morphogenesis : IBA:GO_Central
- cerebral cortex development : IBA:GO_Central
- chemical synaptic transmission : IBA:GO_Central
- convergent extension : IBA:GO_Central
- dopaminergic neuron differentiation : ISS:ParkinsonsUK-UCL
- embryonic pattern specification : IBA:GO_Central
- embryonic retina morphogenesis in camera-type eye : IBA:GO_Central
- external genitalia morphogenesis : IBA:GO_Central
- face morphogenesis : IBA:GO_Central
- midbrain dopaminergic neuron differentiation : TAS:ParkinsonsUK-UCL
- midbrain-hindbrain boundary development : IBA:GO_Central
- negative regulation of canonical Wnt signaling pathway : TAS:Reactome
- negative regulation of protein kinase activity : IMP:BHF-UCL
- negative regulation of protein phosphorylation : IMP:BHF-UCL
- negative regulation of protein serine/threonine kinase activity : IDA:BHF-UCL
- negative regulation of smooth muscle cell apoptotic process : IMP:BHF-UCL
- neural crest cell differentiation : IDA:BHF-UCL
- neural crest formation : IDA:BHF-UCL
- neural tube closure : IBA:GO_Central
- odontogenesis of dentin-containing tooth : IBA:GO_Central
- pericardium morphogenesis : IBA:GO_Central
- positive regulation of canonical Wnt signaling pathway : IDA:BHF-UCL
- positive regulation of cell cycle : IMP:BHF-UCL
- positive regulation of cytosolic calcium ion concentration : IEA:Ensembl
- positive regulation of DNA binding transcription factor activity : IDA:BHF-UCL
- positive regulation of transcription by RNA polymerase II : IDA:BHF-UCL
- positive regulation of transcription, DNA-templated : IMP:BHF-UCL
- positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification : IDA:BHF-UCL
- primitive streak formation : IBA:GO_Central
- protein localization to plasma membrane : IPI:ParkinsonsUK-UCL
- receptor-mediated endocytosis involved in cholesterol transport : IBA:GO_Central
- regulation of canonical Wnt signaling pathway : IGI:ARUK-UCL
- response to peptide hormone : IEA:Ensembl
- roof of mouth development : IBA:GO_Central
- thalamus development : IBA:GO_Central
- trachea cartilage morphogenesis : IBA:GO_Central
- Wnt signaling pathway : IDA:ParkinsonsUK-UCL
- Wnt signaling pathway involved in dorsal/ventral axis specification : IDA:BHF-UCL
- Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation : TAS:ParkinsonsUK-UCL
- Wnt signaling pathway involved in somitogenesis : IBA:GO_Central
|