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10224

Heparan-sulfate 6-O-sulfotransferase 1 (O60243)

Uniprot ID O60243
Protein Name Heparan-sulfate 6-O-sulfotransferase 1
Gene Name HS6ST1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.615
Function 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. .
GO - Molecular function
  • heparan sulfate 6-O-sulfotransferase activity : IBA:GO_Central
  • sulfotransferase activity : TAS:ProtInc
GO - Biological process
  • angiogenesis : IEA:Ensembl
  • glycosaminoglycan biosynthetic process : TAS:Reactome
  • heparan sulfate proteoglycan biosynthetic process, enzymatic modification : IBA:GO_Central
  • labyrinthine layer blood vessel development : IEA:Ensembl
  • lung alveolus development : IEA:Ensembl
  • neuron development : IMP:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.