CCN family member 1 (O00622)

Uniprot ID	O00622
Protein Name	CCN family member 1
Gene Name	CCN1
Species	Homo sapiens (Human)

Signal peptide^(a)	Y	Secretome P^(b)	0.803
Function	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. .
GO - Molecular function	extracellular matrix binding : IEA:Ensembl heparin binding : IBA:GO_Central insulin-like growth factor binding : IEA:InterPro integrin binding : IBA:GO_Central
GO - Biological process	apoptotic process involved in heart morphogenesis : IEA:Ensembl atrial septum morphogenesis : IEA:Ensembl atrioventricular valve morphogenesis : IEA:Ensembl cell adhesion : IBA:GO_Central cellular protein metabolic process : TAS:Reactome chemotaxis : IEA:UniProtKB-KW chondroblast differentiation : IEA:Ensembl chorio-allantoic fusion : IEA:Ensembl extracellular matrix organization : IEA:Ensembl intussusceptive angiogenesis : IEA:Ensembl labyrinthine layer blood vessel development : IEA:Ensembl negative regulation of apoptotic process : IEA:Ensembl negative regulation of cell death : IBA:GO_Central osteoblast differentiation : IEA:Ensembl positive regulation of BMP signaling pathway : IGI:BHF-UCL positive regulation of bone mineralization : IDA:BHF-UCL positive regulation of cartilage development : IEA:Ensembl positive regulation of cell migration : IDA:BHF-UCL positive regulation of cell-substrate adhesion : IEA:Ensembl positive regulation of ceramide biosynthetic process : IEA:Ensembl positive regulation of cysteine-type endopeptidase activity involved in apoptotic process : IEA:Ensembl positive regulation of osteoblast differentiation : IDA:BHF-UCL positive regulation of osteoblast proliferation : IDA:BHF-UCL positive regulation of phospholipase activity : IEA:Ensembl positive regulation of protein kinase activity : IDA:BHF-UCL positive regulation of protein phosphorylation : IDA:BHF-UCL positive regulation of transcription by RNA polymerase II : IDA:BHF-UCL post-translational protein modification : TAS:Reactome reactive oxygen species metabolic process : IEA:Ensembl regulation of ERK1 and ERK2 cascade : IDA:BHF-UCL ventricular septum development : IEA:Ensembl wound healing, spreading of cells : IDA:BHF-UCL

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}