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10017

Glycerol-3-phosphate phosphatase (A6NDG6)

Uniprot ID A6NDG6
Protein Name Glycerol-3-phosphate phosphatase
Gene Name PGP
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.753
Function Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity). .
GO - Molecular function
  • glycerol-1-phosphatase activity : IEA:UniProtKB-EC
  • glycerol-3-phosphatase activity : IDA:UniProtKB
  • magnesium ion binding : ISS:UniProtKB
  • nucleotide phosphatase activity, acting on free nucleotides : ISS:UniProtKB
  • phosphatase activity : IBA:GO_Central
  • phosphoglycolate phosphatase activity : IDA:UniProtKB
  • protein tyrosine phosphatase activity : ISS:UniProtKB
GO - Biological process
  • dephosphorylation : ISS:UniProtKB
  • glycerol biosynthetic process : IDA:UniProtKB
  • glycerophospholipid metabolic process : IDA:UniProtKB
  • negative regulation of gluconeogenesis : IMP:UniProtKB
  • peptidyl-tyrosine dephosphorylation : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.